Chromosomal Abnormalities and Cytoplasmic Immunoglobulin Light Chain Classes in 8 Ph ’ - Negative Lymphoid Cell
نویسندگان
چکیده
To study the relationship of the Philadelphia chromosome (Ph1) to the pathogenesis of chronic myelogenous leukemia, multiple B-Iymphoid cell lines were established from a patient with Ph’-positive leukemia who was heterozygous for the X-chromosome-linked enzyme glucose-6-phosphate dehydrogenase. Both A and B types of enzyme were found in a 1 :1 proportion in normal tissues. but 45 of 63 (71 %) Ph1-negative B-lymphoid cells lines derived from this patient showed only the single glucose-6-phosphate dehydrogenase (type B) found in the Ph’-positive leukemic clone. Furthermore, 8 of 33 analyzable lines with B-type
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